Cleopatra of Egypt had four children, but only one produced any descendants. But how far did her line extend?
Cleopatra VII, the last pharaoh of an independent Egypt, had four children: Caesarion (with Julius Caesar), twins Alexander Helios and Cleopatra Selene, and Ptolemy Philadelphus (the latter three with Mark Antony). But she only had descendants through one of her children: her sole daughter, Selene, who married King Juba II of Mauretania.
Source: Did Descendants of Cleopatra VII Survive and Produce the Legendary Queen Zenobia of Palmyra? | Ancient Origins